Answer: In the case of grossly deformed kittens, it is much the kindest thing to have them put to sleep immediately; indeed, they may vey well not survive long in any case. The deformities include such thing as spina bifida (where the spinal cord is exposed), gross umbilical hernia (where most of the intestines are outside of the body, covered only by a pouch of skin), and the most common, a severe cleft plate. Other abnormalities such as extra toes or shortened tails, however, will not present any danger to health. If there is any doubt it is always worth discussing with your vet the chance of successfully treating and rearing a particular kitten.
Unwanted kittens i.e. those for which no home can be found, are best put to sleep humanely as soon as possible. This often means having to the harden your heart, but it is preferable to increasing the stray cat population. Where possible, two kittens should be left to suckle the mother, no only because of its beneficial psychological effect, but also because it may prevent her developing mastitis subsequently. Where it is necessary, unwanted kitten should always be put to sleep by your veterinarian and not disposed of by other methods such as drowning which is extremely unpleasant and inhumane.